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For more blow-by-blow in-formation on the etiologies of CP, readers are referred to the list The Cere-bral Palsies before Miller and Clarke,1which provides much greater specifics on thisspecific topic.

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Appropriate endpoints throughout clinical trials should contemplate the acquirement of clinical gain that is defined as improve- ment of lone or more of the following prejudiced and open-minded endpoints: toxicity, time without symptoms, submissive reported outcomes PRO , progression-free survival PFS , and overall survival OS.

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